Typical applications of DLS are particle size analysis, screening of buffer conditions during formulation, stability testing, and aggregation analysis. On the one hand many application for example in the protein research or analysis of liposomes and micelles cannot be performed by means of other. It can thereby be applied to everything from antibody, peptides and proteins, to nanoparticles and viruses. The dynamic light scattering (DLS) is a technique to measure the particle size distribution of nano- and submircosized particles, which is used primarily in pharmaceutical and biochemical industry. Applicability:ĭynamic light scattering (DLS) is applicable to particles and macromolecules from ~ 1 nm to ~1 µm. The measured Brownian motion is related to the diffusion coefficient and from that the hydrodynamic size (Stokes radius) can be obtained. Principle:ĭynamic light scattering (DLS), also referred to as quasi-elastic light scattering (QELS) or photon correlation spectroscopy (PCS), is a spectroscopic technique that measures the Brownian motion of particles/macromolecules in solution. We use DLS instrumentation from Wyatt Technology and Malvern. Dynamic Light Scattering Particle size measurement using multiangle dynamic light scattering The dynamic light scattering (DLS) is a technique to measure the particle size distribution of nano- and submircosized particles, which is used primarily in pharmaceutical and biochemical industry. Our instrumentation is temperature controlled which is handy for stability investigations. We have the traditional DLS cuvette format, but also a DLS plate reader for high-throughput analysis and screenings, that utilizes low sample volumes. Dynamic Light Scattering (DLS), sometimes referred to as Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering, is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid. A typical use of dynamic light scattering (DLS) at SOLVE is particle size analysis and screening of protein solutions for aggregates.
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